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KMID : 0914820030030010038
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Journal of the Korean Gastric Cancer Association
2003 Volume.3 No. 1 p.38 ~ p.43
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Expression pattern of Caspase 2 in Korean Gastric Cancers
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Park Won-Sang
Park Jik-Young
Lee Jong-Heun
Cho Yong-Gu
Lee Jong-Woo
Song Young-Hwa
Kim Young-Sil
Park Cho-Hyun
Nam Suk-Woo
Lee Sug-Hyung
Yoo Nam-Jin
Lee Jung-Yong
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Abstract
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Purpose: Caspase 2, a member of the family of ICE-like proteases, is activated by the Fas pathway and induces apoptosis by triggering the caspase cascade. The purpose of this study was to determine whether the expression pattern of caspase 2 might be associated with gastric cancer development and if so, to determine to which pathologic parameter it is linked.
Materials and Methods: For the construction of the gastric cancer tissue microarray, 78 paraffin-embedded tissues containing gastric cancer areas were cored 3 times and transferred to the recipient master block. The expression pattern of caspase 2 was examined on tissue microarray slides by using immunohistochemistry and was compared with pathologic parameters, including histologic type, depth of invasion, lymph node metastasis, and peritoneal dissemination.
Results: Caspase 2 was expressed on superficial and foveolar epithelial cells and lymphocytes in the gastric mucosa, mainly in cytoplasm. We found loss of caspase 2 expression in 41 (52.6%) of the 78 gastric cancer tissues. Statistically, histologic type and other pathologic parameters were not related with loss of caspase 2 expression.
Conclusion: Our findings provide enough evidence that loss of caspase 2 expression may contribute to the development of Korean gastric cancer and that it might be one of the possible escape mechanisms from apoptosis in gastric cancer.
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KEYWORD
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Apoptosis, Caspase, Immunohistochemistry, Stomach cancer
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